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Donate Toggle navigation Menu Apply Department Faculty Ph.D. Program Postdoctoral Program Publications Diversity & Outreach Alumni Illustration by Layla Lang Illustration by Layla Lang Illustration by Layla Lang SAVE THE DATE! CSB Scientific Retreat, September 11-13, 2024, Asilomar Conference Grounds, Pacific Grove, CA! About Ph.D. Program Postdoctoral Program CHEMICAL AND SYSTEMS BIOLOGY The Department of Chemical and Systems Biology explores the molecular mechanisms that underlie cellular function and contribute to human disease. Our laboratories emphasize interdisciplinary research that spans the biomedical sciences, including signal transduction, cell cycle regulation, chromatin remodeling, protein homeostasis, metabolism, and cell differentiation. By integrating genetic technologies, biochemical and chemical tools, quantitative measurements, and computational modeling, we strive to deconstruct these complex biological systems, predict emergent behaviors, and translate these discoveries into new medical therapies. Learn More » Welcome to CSB! The Chemical and Systems Biology Graduate Program trains students to explore the function of complex biological systems at a quantitative and molecular level. Research in our laboratories combines state-of-the-art approaches from chemistry, biochemistry, cell biology, genomics, computational modeling, and other disciplines to understand cellular and organismal physiology, predict emergent behaviors, and translate these discoveries into new technologies and therapies. Our faculty members are internationally renowned scientists who foster an innovative and collaborative research environment, and alumni from our home program are leaders in academics, biotech, and science policy. Learn More » Postdoctoral Program Postdoctoral fellows are an integral part of the Chemical and Systems Biology community, playing active roles in its research and training activities. Fellows join the Chemical and Systems Biology Postdoctoral Program through individual laboratories, and interested applicants should contact faculty members directly. Learn More » FACULTY SEARCH: Tenure-track Assistant or Associate Professor position in the University Tenure Line in the Department of Chemical and Systems Biology at the Stanford University School of Medicine. [PDF] News CSB Monthly Birthday Celebration! May 17, 2024 CSB Special Seminar: Steffen Lindert, Ph.D., May 15, 2024 Publications Extracellular release of mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates GVHD. An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome. Events / Calendar CSB Special Seminar: Steffen Lindert, Ph.D., Wednesday, May 15, 2024 Next Steps Our Department » Chair Welcome Letter » Explore The Labs View All Faculty » Chen Lab Research Focus Developmental signaling pathways and their roles in embryonic patterning and oncogenesis; zebrafish models of tissue patterning and regeneration; synthetic chemistry and chemical biology. Publication TBX16 Regulates Hox Gene Activation In Mesodermal Progenitor Cells. Lab Website » View All Faculty » Chistol Lab Research Focus Chistol Lab is using real-time single-molecule imaging to: (i) study how eukaryotes replicate/repair their DNA, (ii) dissect molecular mechanisms involved in maintaining large/complex genomes, and (iii) understand how massive multi-subunit molecular machines like the replisome are regulated. Publication The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair. Lab Website » View All Faculty » Cimprich Lab Research Focus Genome stability pathways and their roles in cancer and other human diseases; DNA damage response pathways and DNA replication; the interface between RNA processing and transcription with genome stability. Publication Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses. Lab Website » View All Faculty » Ferrell Lab Research Focus Cell cycle regulation, especially M-phase regulation, in Xenopus embryos and mammalian cell lines; systems biology of signal transduction pathways. Publication Thresholds And Ultrasensitivity From Negative Cooperativity. Lab Website » View All Faculty » Gray Lab Research Focus Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug development, as it can address previously inaccessible targets... Publication Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development Lab Website » View All Faculty » SPARK Research Focus Translation of promising research discoveries into novel therapeutics and diagnostics; discovery and development of new drugs, biologics, and diagnostics; repurposing existing drugs against new targets for new clinical indications. Publication A Practical Guide to Drug Development in Academia: the SPARK Approach. SPARK Program » View All Faculty » Jarosz Lab Research Focus Protein conformational switches in evolution, disease, and development; molecular mechanisms driving mutational robustness in pathogens and cancer in complex cellular systems; chemical biology, cell signaling, and quantitative genetics. Publication Intrinsically Disordered Proteins Drive Emergence And Inheritance Of Biological Traits. Lab Website » View All Faculty » Martinez Lab Research Focus The Martinez lab studies RNA regulatory mechanisms that control gene expression. We focus on mRNA processing, RNA modifications and their roles in development and disease. Publication Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. Lab Website » View All Faculty » Mochly-Rosen Lab Research Focus Protein kinase C signaling in normal & disease states; mitochondrial function and dynamics in normal & disease states; oxidative stress and aldehydic load; protein-protein interaction; drug discovery. Publication Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics. Lab Website » View All Faculty » Rogala Lab Research Focus How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as hormones, to determine cellular decisions, especially the decision: to grow or not to grow? We are a team of structural and chemical biologists aiming to answer these questions at the level of ångstroms, nanometers, and micrometers. Many proteins in these pathways are deregulated in cancer, and we are developing targeted chemical probes to modulate their activity in cells and organisms. Publication Structural basis for the docking of mTORC1 on the lysosomal surface. Lab Website » View All Faculty » Wandless Lab Research Focus Cellular mechanisms responsible for protein quality control surveillance and degradation; invention of new technologies to enable biomedical research; synthetic chemistry and chemical biology. Publication A method to rapidly create protein aggregates in living cells. Lab Website » View All Faculty » Wysocka Lab Research Focus Epigenetic regulation of development; cis-regulatory elements; chromatin modification and remodeling; stem cell self-renewal and differentiation; neural crest and formation of the human face. Publication Ever-Changing Landscapes: Transcriptional Enhancers In Development And Evolution. Lab Website » View All Faculty » Explore: Apply Department Faculty Ph.D. Program Postdoctoral Program Publications Alumni Connect: StanfordMed TODAY Facebook LinkedIn Twitter YouTube Contact: CCSR Building James H. Clark Center Lokey Stem Cell Research 269 Campus Drive CCSR 4145 Stanford, CA 94305 Phone: 650.723.9785 318 Campus Drive Clark W2.1 Stanford, CA 94305 Phone: 650.723.9785 265 Campus Drive SIM1 G3078A Stanford, CA 94305 Phone: 650.723.9785 Stanford Home Maps & Directions Search...